Engineering Mosquitos to Fight Malaria

Mosquitos are the deadliest animal on Earth. They spread diseases like yellow fever, chikungunya, West Nile virus and malaria. Malaria alone killed 435,000 people and infected another 219 million in 2017 according to the World Health Organization. There are widespread efforts to combat mosquito-borne illnesses, including revolutionary new gene editing techniques.

Ethan Bier and Valentino Gantz, biologists at UC San Diego, have been researching gene drives – systems that allow scientists to quickly push genes through entire populations. Typically, genetic information from each parent is combined and passed down to their children. Think back to Punnett squares from high school biology. If one parent has blonde hair and the other has brown hair, the brunette would have to carry a recessive blonde gene for any of their children to be blonde. But, gene drives change that. Gantz and Bier came up with a way to use the CRISPR gene-editing technique to insert self-editing genes into mosquitos, so preferred traits are always passed down. Their research shows these traits can take over entire populations within 10 generations, one to two years for mosquitos.

In a recent talk at UC San Diego Extension’s Osher Lifelong Learning Institute, Bier dove into the details of exactly how gene drives work, and their many potential applications.

Watch — Engineering Mosquitos to Fight Malaria with Ethan Bier — Osher UC San Diego