Humans have a relatively high risk of developing cancer in their lifetimes. But cancer is not unique to humans. Across the tree of life, we can trace cancer vulnerabilities back to the origins of multicellularity. Cancer is observed in almost all multicellular phyla, including lineages leading to plants, fungi, and animals.
However, species vary remarkably in their susceptibility to cancer. And some organisms are much better at killing problem cells. Amy Boddy discusses how this variation is characterized by life history trade-offs, especially longevity. Interestingly, different species have evolved different ways to fight cell mutations that cause cancer. This may lead to a better understanding of cancer susceptibility across human populations.
Amy Boddy is an Assistant Professor in the Integrated Anthropological Sciences Unit and a Research Associate in the Broom Center for Demography at UC Santa Barbara. Boddy completed her PhD in molecular biology and genetics at the Wayne State University – School of Medicine in 2013. Her work uses applications from evolution and ecology to understand human health and disease. She uses a combination of genomics, computational biology and evolutionary theory to understand life history trade-offs between survival and reproduction across different levels of biological organization. One component of her research program examines how environmental cues, such as high extrinsic mortality, may guide resource allocations to cancer defenses and reproduction. Current cancer research topics include comparative oncology, intragenomic conflict, cellular life history trade-offs, and early life adversity and cancer outcomes later in life. In addition to her cancer research, she studies maternal/fetal conflict theory and the consequences of fetal microchimeric cells in maternal health and disease.
Watch Cancer Across the Tree of Life: New Insights into an Ancient Disease
Try to remember the first time in your life when you imagined something. It may have been imagining what was behind the door or under the bed, or a fantastic universe of wonders and exciting adventure. As children, our imaginations are furtive and encouraged as ways in which we develop our cognitive capabilities. As we grow older, we may not imagine in quite the same ways, but we continue to heavily use and depend on our imagination in our daily lives, imagining different situations that might occur in a few moments or in a few years. Thus, we actually spend a large amount of time in our own particular universe imagining many possible different ones.
Why do we do this and how did this capacity evolve in humans? Imagination probably helped our ancestors to be successful in making decisions and live in complex societies, and imagination is key to advancing technology. In this CARTA symposium, imagination is explored as a unique and enhanced human ability, and experts from all fields discuss its evolutionary origins, the fundamental genetic and neurological basis of human imagination, the impact of human imagination in science and art, and the consequences of imagination impairment.
Browse more programs in CARTA: Imagination and Human Origins
Humans have been hunter-gatherers for most of our existence as a species and hunting has long been seen as a key human adaptation, thought to have influenced our anatomy, physiology, and behavior, indeed, a force in our evolution as a species. CARTA brings experts from across the globe to explore evidence pertaining to understanding the origins of hominin hunting and where this understanding can lead future research.
Browse more programs in CARTA: The Role of Hunting in Anthropogeny.
Remember Dolly the sheep? How in 1996 she made international news as the first cloned mammal? Now, imagine using those techniques to bring back extinct animals, such as the mammoth or the passenger pigeon. While the concept may no longer be science fiction, the costs and consequences of this research are still unknown. MacArthur Award recipient and evolutionary biologist Beth Shapiro of UC Santa Cruz discusses the scientific and ethical questions raised by what’s known as Ancient DNA research in this fascinating talk presented by the new Institute for Practical Ethics at UC San Diego.
Watch Can We, Should We, and Will We Bring Back Mammoths? with Beth Shapiro .
Despite discoveries of remarkable new fossils in recent years, the evolutionary events surrounding the origins of genus Homo are incompletely understood.
This fascinating CARTA symposium explores evidence bearing on the emergence of our genus. What forces caused the changes in diet and body form as our predecessors evolved toward Homo. Were there forces from within on the molecular scale? Or changes in environment and climate? How did an integrated suite of behaviors, collectively termed hunting and gathering, that emerged sometime between 3 and 2 million years ago affect changes that spurred evolution towards the characteristics which are all associated with our human lineage?
Watch as a diverse cadre of experts from around the world present their observations on the Origins of Genus Homo.
Browse all episodes in CARTA: Origins of Genus Homo