Tag Archives: genomics

Cancer from an Evolutionary Perspective

Humans have a relatively high risk of developing cancer in their lifetimes. But cancer is not unique to humans. Across the tree of life, we can trace cancer vulnerabilities back to the origins of multicellularity. Cancer is observed in almost all multicellular phyla, including lineages leading to plants, fungi, and animals.

However, species vary remarkably in their susceptibility to cancer. And some organisms are much better at killing problem cells. Amy Boddy discusses how this variation is characterized by life history trade-offs, especially longevity. Interestingly, different species have evolved different ways to fight cell mutations that cause cancer. This may lead to a better understanding of cancer susceptibility across human populations.

Amy Boddy is an Assistant Professor in the Integrated Anthropological Sciences Unit and a Research Associate in the Broom Center for Demography at UC Santa Barbara. Boddy completed her PhD in molecular biology and genetics at the Wayne State University – School of Medicine in 2013. Her work uses applications from evolution and ecology to understand human health and disease. She uses a combination of genomics, computational biology and evolutionary theory to understand life history trade-offs between survival and reproduction across different levels of biological organization. One component of her research program examines how environmental cues, such as high extrinsic mortality, may guide resource allocations to cancer defenses and reproduction. Current cancer research topics include comparative oncology, intragenomic conflict, cellular life history trade-offs, and early life adversity and cancer outcomes later in life. In addition to her cancer research, she studies maternal/fetal conflict theory and the consequences of fetal microchimeric cells in maternal health and disease.

Watch Cancer Across the Tree of Life: New Insights into an Ancient Disease

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J. Craig Venter: Manufacturing Life with Synthetic DNA

The future is here. At least it feels that way after watching one of the most buzzed-about panels from The Atlantic Meets the Pacific forum held at UC San Diego in October.

In “Manufacturing Life: How Synthetic DNA Will Change Our World,” Editor-in-Chief of The Atlantic, James Bennet, chats with J. Craig Venter, CEO of Synthetic Genomics and one of the first to sequence the human genome, about finding genomic-driven solutions to address global needs such as new sources of energy, food and vaccines. The program is introduced by Pradeep Khosla, UC San Diego’s new chancellor.

Watch it online now.

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