“All the best models are the ones that you can improve in complexity to get closer and closer to the reality.”
The idea of a brain in a dish may sound like science fiction to some but scientists are becoming more and more adept at creating cortical organoids in the lab. The organoids are models of what is happening in utero as the brain forms. Being able to study this kind of human development not only opens new insights into neurological conditions but raises ethical questions.
Alysson Muotri, director of the UC San Diego Stem Cell Program, gives a look at how his lab is using these organoids to model specific conditions, treat disease, and explore fundamental brain mechanisms. Learn what the limitations, future projections, and ethical concerns are surrounding this exciting science.
Watch Re-constructing Brains in the Lab to Revolutionize Neuroscience – Exploring Ethics
Try to remember the first time in your life when you imagined something. It may have been imagining what was behind the door or under the bed, or a fantastic universe of wonders and exciting adventure. As children, our imaginations are furtive and encouraged as ways in which we develop our cognitive capabilities. As we grow older, we may not imagine in quite the same ways, but we continue to heavily use and depend on our imagination in our daily lives, imagining different situations that might occur in a few moments or in a few years. Thus, we actually spend a large amount of time in our own particular universe imagining many possible different ones.
Why do we do this and how did this capacity evolve in humans? Imagination probably helped our ancestors to be successful in making decisions and live in complex societies, and imagination is key to advancing technology. In this CARTA symposium, imagination is explored as a unique and enhanced human ability, and experts from all fields discuss its evolutionary origins, the fundamental genetic and neurological basis of human imagination, the impact of human imagination in science and art, and the consequences of imagination impairment.
Browse more programs in CARTA: Imagination and Human Origins
Using brains-in-a-dish (cortical organoids), the Muotri Lab at UC San Diego has developed a new treatment for Aicardi-Goutieres syndrome. This study not only identified the underlying mechanisms that drive AGS but has also led to surprising revelations about neuroinflammation. Learn how they repurposed HIV antiretroviral drugs to rescue mutated cells and what this research means for studying other neurological conditions such as autism and schizophrenia.
Watch: Reconstructing the Brain in a Dish: Emergence of Neuroinflammation from Retrotransposons