Inside a lab at the Sanford Consortium for Regenerative Medicine, researchers are doing something truly remarkable. They are growing tiny versions of developing human brains in order to study everything from Alzheimer’s disease to the Zika virus. Alysson Muotri is the co-director of the UC San Diego Stem Cell Program and leads the team researching brain organoids. He recently sat down with Dr. David Granet on Health Matters to discuss the endless possibilities of his research.
Muotri’s organoids are often referred to as “mini-brains,” but they are far from what that name might suggest. The organoids are grown from stem cells, which are harvested from living tissue, such as skin cells. Researchers give those stem cells instructions to become neural cells. Eventually they form tiny clusters of neural cells, about the size of a pea. Those clusters have been shown to exhibit some of the same characteristics of developing human brains, including firing electrical signals in specific patterns. But, the organoids do not contain every type of brain tissue, and have no vascularization.
Despite the differences with the human brain, organoids have proven useful in understanding and treating disease. One of the major successes of Muotri’s research was finding and testing an existing drug to treat mothers infected with Zika virus. The drug can prevent the disease from being passed to the baby and causing microcephaly. Muotri is hoping his lab will continue to have success using the organoids as an effective brain model to find more cures, and provide a deeper understanding of brain development and disease. And, his work isn’t limited to Earth. Muotri recently launched his organoids into space for a groundbreaking study.
Check out highlights from this year’s conference addressing a variety of topics, including the impact of trauma and immigration on child development and people with intellectual and developmental disabilities.
Offering a unique update for primary care and subspecialty health care professionals and others who care for children, youth, and adults with developmental disabilities and complex health care needs, the conference covered a broad spectrum of developmental disabilities across the lifespan including autism spectrum disorders, mental health, genetic screening and diagnoses, and intervention and therapeutic consideration. Focus on special education, law enforcement, and policy from a variety of specialists adds to the content.
Presentations by expert faculty should be of interest to pediatricians, family physicians, nurse clinicians, psychologists, and internists who are involved in the healthcare of individuals with developmental disabilities, as well as to those in other health-related disciplines including health policy, epidemiology, psychiatry, school health, social work, and case management services.
While the conference is designed for health care professionals, families and individuals with developmental disabilities will also learn from the various represented disciplines. The conference was held at UCSF on March 14 and 15, 2019.
Yesterday, President Barack Obama announced his plans to create a bold, $100 million public-private initiative to better understand the brain and the diseases that affect it. Appropriately called BRAIN (for Brain Research through Advancing Innovative Neurotechnologies), the group brings together experts across private industry, academia and government agencies in the areas of neuroscience, neurotechnology and neuroscience.
And it seems our viewers are always hungry for more. UCTV’s Human Brain iTunes feed consistently shows up in iTunesU’s Top 10 Collections and “What’s Hot” sections.
No doubt that President Obama’s endorsement will mean even more exciting discoveries — and UCTV programs — to come. In the meantime, subscribe to our Human Brain feed in iTunes and browse our archive of Neurology programs at our website. There’s plenty to keep your brain busy!