Tag Archives: CRISPR

Medicine of the Future

UCSF has a long history of pioneering biomedical research and a bold vision for advancing science and seeking new ways to improve health care delivery nationwide. But, what does that actually mean in the near future and beyond?

This new series, part of the popular Mini Medical School for the Public, takes you inside the work of UCSF scientists to learn what the next decade may bring to the world of medicine. Hailing from a wide spectrum of disciplines, each explores a different topic that has the potential to impact the future of healthcare.

UCSF was the only medical school to be ranked in the top five in the nation in both research and primary care by US News and World Report, ranking fifth in biomedical research and third in primary care education. UCSF was also the only medical school ranked in the top five in all eight of the specialty areas covered by the survey in 2019.

Browse more programs in Next: UCSF Scientists Outline What’s To Come .

facebooktwittergoogle_plus

Editing the Code of Life

You may not know what clustered regularly interspersed short palindromic repeats means, but when you see or hear the word CRISPR it all takes on new meaning, thanks to the efforts of UC Berkeley’s Jennifer Doudna and her collaborator Emmanuelle Charpentier, who developed this revolutionary method of genomic editing.

Her work has literally changed the world with her research, with tremendous benefits for the future of humankind and the planet.

The discovery of CRISPR-Cas9 genetic engineering technology has changed human and agricultural genomics research forever. This genome-editing technology enables scientists to change or remove genes quickly and with extreme precision. Labs worldwide have changed the course of their research programs to incorporate this new tool, creating a CRISPR revolution with huge implications across biology and medicine.

This talk marks the occasion of Doudna receiving the UC San Diego Scripps Institution of Oceanography’s 2019 Nierenberg Prize for Science in the Public Interest.

Watch — Editing the Code of Life: Into the Future with CRISPR Technology with Jennifer Doudna – 2019 Nierenberg Prize for Science in the Public Interest

facebooktwittergoogle_plus

Combatting the Scourge

Malaria has been described as “the perennial scourge of mankind,” with over 200 million cases reported annually resulting in up to 750,000 deaths and incalculable misery. The disease is most common in the tropical and subtropical regions that surround the equator, including Sub-Saharan Africa, Latin America, and Asia, but it may be found in any region where climatic conditions favor the growth and spread of the mosquito-borne parasite.

On-going global eradication efforts employing pesticides have been successful in southern Europe and the southern United States, but less so elsewhere. In recent years genomics has taken center stage in malaria research with the sequencing of both the malarial parasite and the human genome. One experimental application of this research is the production of genetically-modified mosquitoes that do not transmit malaria. Another new and promising technique is the gene drive, which combats malaria by introducing disruptive genes into wild populations of mosquitoes that interfere with the development of females.

The use of such radical measures unavoidably prompts serious bioethical concerns, including the possibilities of unforeseen mutations and broader ecological impacts. Ethicists also question whether we have the right to potentially eliminate a species. In her self-described role as a “moral philosopher” Laurie Zoloth (University of Chicago) has written and lectured extensively about these issues, arguing that:

In the 1960s, the world agreed that smallpox was a species worth eliminating. We should feel the same way about A. gambiae. And isn’t deploying a gene drive that specifically targets the mosquito species that carries malaria far better than using chemical sprays, such as pyrethroids, organochlorines and DDT (still used in some countries) that indiscriminately target any insect?

Though malaria and other insect-borne diseases have historically been associated with Third World poverty, Zoloth notes these maladies are no longer the exclusive province of underdeveloped tropical countries. As climate change results in greater and more widespread extremes of temperature, rainfall, and humidity, the range of mosquitoes is likely to increase, and with them the diseases they transmit including malaria, dengue, yellow fever, and Zika. While acknowledging the dangers of meddling with the genetic status quo, Zoloth maintains that preoccupation with those risks is a luxury afforded only to those who are not at risk of losing a loved one to wrenching fevers and severe dehydration.

Zoloth concludes that in that light, gene drives and other genomic-based eradication methods represent the most moral and ethical choice available to scientists.

Watch May We Make the World?: Religious and Ethical Questions with Dr. Laurie Zoloth – Burke Lectureship

facebooktwittergoogle_plus