Tag Archives: mini brains

Neuroscience, Mini Brains, and Your Health

“All the best models are the ones that you can improve in complexity to get closer and closer to the reality.”

The idea of a brain in a dish may sound like science fiction to some but scientists are becoming more and more adept at creating cortical organoids in the lab. The organoids are models of what is happening in utero as the brain forms. Being able to study this kind of human development not only opens new insights into neurological conditions but raises ethical questions.

Alysson Muotri, director of the UC San Diego Stem Cell Program, gives a look at how his lab is using these organoids to model specific conditions, treat disease, and explore fundamental brain mechanisms. Learn what the limitations, future projections, and ethical concerns are surrounding this exciting science.

Watch Re-constructing Brains in the Lab to Revolutionize Neuroscience – Exploring Ethics

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Aicardi-Goutieres: A Rare Disorder, A Unique Look into the Brain

8232Using brains-in-a-dish (cortical organoids), the Muotri Lab at UC San Diego has developed a new treatment for Aicardi-Goutieres syndrome. This study not only identified the underlying mechanisms that drive AGS but has also led to surprising revelations about neuroinflammation. Learn how they repurposed HIV antiretroviral drugs to rescue mutated cells and what this research means for studying other neurological conditions such as autism and schizophrenia.

Watch: Reconstructing the Brain in a Dish: Emergence of Neuroinflammation from Retrotransposons

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