Category Archives: Bioscience

Engineering Mosquitos to Fight Malaria

Mosquitos are the deadliest animal on Earth. They spread diseases like yellow fever, chikungunya, West Nile virus and malaria. Malaria alone killed 435,000 people and infected another 219 million in 2017 according to the World Health Organization. There are widespread efforts to combat mosquito-borne illnesses, including revolutionary new gene editing techniques.

Ethan Bier and Valentino Gantz, biologists at UC San Diego, have been researching gene drives – systems that allow scientists to quickly push genes through entire populations. Typically, genetic information from each parent is combined and passed down to their children. Think back to Punnett squares from high school biology. If one parent has blonde hair and the other has brown hair, the brunette would have to carry a recessive blonde gene for any of their children to be blonde. But, gene drives change that. Gantz and Bier came up with a way to use the CRISPR gene-editing technique to insert self-editing genes into mosquitos, so preferred traits are always passed down. Their research shows these traits can take over entire populations within 10 generations, one to two years for mosquitos.

In a recent talk at UC San Diego Extension’s Osher Lifelong Learning Institute, Bier dove into the details of exactly how gene drives work, and their many potential applications.

Watch — Engineering Mosquitos to Fight Malaria with Ethan Bier — Osher UC San Diego

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The CRISPR Revolution

Jennifer Doudna is a leader in the CRISPR revolution. This new technology is a gene editing tool that manipulates DNA within organisms. The editing process has a wide variety of applications including correcting genetic defects, treating and preventing the spread of diseases and improving crops.

Doudna, Professor of Biochemistry, Biophysics and Structural Biology at UC Berkeley, sat down to talk with Harry Kreisler about her life and how she came to be involved in this amazing discovery.

They also discuss how education and public advocacy can broaden insight into the ethical and policy dimensions of the biological revolution that is upon us.

Watch Unraveling CRISPR-Cas9 with Jennifer Doudna – Conversations with History

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Marvelous Machines

Lawrence Livermore National Laboratory’s popular lecture series, “Science on Saturday,” returns to UCTV with four different lectures, each exploring the theme “Marvelous Machines.” These presentations are targeted to middle and high school students so we can all get our science on.

Checkout these lectures:
Biomolecular Action Movies: Flash Imaging With X-ray Lasers, with Matthias Frank and Megan Shelby

Biomedical Accelerator Mass Spectrometry: Improving Human Health One Atom at a Time with scientist Mike Malfatti

Laser Plasma Accelerators: Riding the Wave to the Next Generation X-Ray Light Source, by Felicie Albert

The Evolution of Computing Technologies: From Following Instructions to Learning, by Katherine Lewis

Browse more programs in Field Trip at the Lab: Science on Saturday.

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