You may not know what clustered regularly interspersed short palindromic repeats means, but when you see or hear the word CRISPR it all takes on new meaning, thanks to the efforts of UC Berkeley’s Jennifer Doudna and her collaborator Emmanuelle Charpentier, who developed this revolutionary method of genomic editing.
Her work has literally changed the world with her research, with tremendous benefits for the future of humankind and the planet.
The discovery of CRISPR-Cas9 genetic engineering technology has changed human and agricultural genomics research forever. This genome-editing technology enables scientists to change or remove genes quickly and with extreme precision. Labs worldwide have changed the course of their research programs to incorporate this new tool, creating a CRISPR revolution with huge implications across biology and medicine.
This talk marks the occasion of Doudna receiving the UC San Diego Scripps Institution of Oceanography’s 2019 Nierenberg Prize for Science in the Public Interest.
Watch — Editing the Code of Life: Into the Future with CRISPR Technology with Jennifer Doudna – 2019 Nierenberg Prize for Science in the Public Interest
As recent events have shown, strong winds can spell disaster, even without the presence of fire. But when a fire does occur, the ALERTWildfire camera network deployed across the region provides rapid confirmation of emergency wildfire 911 calls, situational awareness, and in the worst-case scenarios, real-time data to help sequence evacuations.
ALERTWildfire is a consortium of three universities: University of Nevada at Reno, UC San Diego, and University of Oregon. During the past three fire seasons (2016-2018), ALERTWildfire provided critical information for over 600 fires, including the Woolsey, Lilac, Wall, Whittier, Thomas, Tule, Woodchuck, Earthstone, Truckee, Draw, Snowstorm, Hot Pot, and Emerald fires; a 2016 arson spree in Lake Tahoe; and hundreds more.
Join Neal Driscoll to learn how California is using technology to help firefighters and improve public preparedness during wildfire disasters.
Watch — Bracing for Fire When the Wind Blows
Inside a lab at the Sanford Consortium for Regenerative Medicine, researchers are doing something truly remarkable. They are growing tiny versions of developing human brains in order to study everything from Alzheimer’s disease to the Zika virus. Alysson Muotri is the co-director of the UC San Diego Stem Cell Program and leads the team researching brain organoids. He recently sat down with Dr. David Granet on Health Matters to discuss the endless possibilities of his research.
Muotri’s organoids are often referred to as “mini-brains,” but they are far from what that name might suggest. The organoids are grown from stem cells, which are harvested from living tissue, such as skin cells. Researchers give those stem cells instructions to become neural cells. Eventually they form tiny clusters of neural cells, about the size of a pea. Those clusters have been shown to exhibit some of the same characteristics of developing human brains, including firing electrical signals in specific patterns. But, the organoids do not contain every type of brain tissue, and have no vascularization.
Despite the differences with the human brain, organoids have proven useful in understanding and treating disease. One of the major successes of Muotri’s research was finding and testing an existing drug to treat mothers infected with Zika virus. The drug can prevent the disease from being passed to the baby and causing microcephaly. Muotri is hoping his lab will continue to have success using the organoids as an effective brain model to find more cures, and provide a deeper understanding of brain development and disease. And, his work isn’t limited to Earth. Muotri recently launched his organoids into space for a groundbreaking study.
Watch — Using Stem Cells to Research the Brain – Health Matters
“This is what I learned when I thought I knew everything already about healthy eating and living,” says Vicky Newman, MS, RDN. Her informative talk goes beyond the basics of calcium intake for bone health to highlight the importance of a healthy diet combined with physical activity. Learn about the exercises that increase weight bearing and strength in addition to activities to improve your balance. Get insights into what a bone-healthy diet looks like and how to work with your doctor to minimize medications that could be taking a toll on your bones.
“Boosting Bone Health to Prevent Injury and Speed Healing” marks the 2019 return of the Stein Institute for Research on Aging lecture series to UCTV. For more with Vicky Newman, and to view the complete archive of lectures, visit https://uctv.tv/stein/.
Watch — Boosting Bone Health to Prevent Injury and Speed Healing – Research on Aging
The 2019 edition of UC San Diego Geisel Library’s “Dinner in the Library” series celebrates new acquisitions from the estate of Theodor “Dr. Seuss” Geisel, most of which have never before been exhibited publicly. The Library’s Special Collections already houses over 20,000 items related to Geisel, including sketches, paintings, cartoons, letters, and manuscripts, and these new arrivals will further enhance its status as the world’s premiere repository of Seuss miscellany.
University Librarian Erik Mitchell welcomes a distinguished panel to discuss their reactions to the unveiling of Geisel’s “private art.” Seth Lerer, moderator and Distinguished Professor of Literature at UC San Diego, traces the development of Geisel’s stylistic vocabulary though doodles and rough sketches not intended for publication, and invites fellow panelists and the audience to consider the proper placement of these works within Geisel’s larger oeuvre. Rob Sidner, Executive Director of the Mingei International Museum, notes that many of the new acquisitions were exhibited in Geisel’s home and speculates on their personal significance to the artist. Mary Beebe, Director of the Stuart Collection at UC San Diego, discusses Geisel’s acrylic paintings on display, noting they are uncharacteristic of Geisel and yet valuable for that reason. Beebe also cites Geisel’s delight in wordplay as a consistent feature of his work.
Other topics featured in this wide-ranging discussion include the challenges of exposure to a hitherto-unknown facet of an artist’s work, influences on Geisel’s development such as theatre and Surrealism (most notably Salvador Dali), the underlying social commentary in many of Geisel’s cartoons and books, his frequent portrayals of “sympathetic monsters,” and the importance of acknowledging that, in Seth Lerer’s words, “not everything in this collection is happy or funny; some of it is in fact quite dark.”
Theodor Geisel famously maintained that he wrote his books for adults, and that their adoption as beloved icons of children’s literature was a fortunate happenstance. The new additions to the Geisel Library’s Special Collections contribute to a fuller portrait of this complex and prolific artist, one possessed of considerable skills whose range of styles and thematic concerns is greater than previously appreciated.
Watch — The Private Art of Theodor “Dr. Seuss” Geisel – Dinner in the Library 2019